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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan EQUILIBRIUM Majalah Kedokteran Gigi Indonesia Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions Multidiciplinary Journal Medical Technology and Public Health Journal Jurnal Mekanova : Mekanikal, Inovasi dan Teknologi Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Indonesian Journal of electronics, electromedical engineering, and medical informatics Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Journal of Telenursing (JOTING) Jurnal Surya Muda: Ilmu Keperawatan dan Ilmu Kesehatan AloHA International Journal of Health Advancement (AIJHA) Hang Tuah Medical Journal Journal for Quality in Public Health
Al Munawir
Department Of Pathology, Faculty Of Medicine, University Of Jember, Jember, 68121 Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Mechanical Engineering Medicine & Pharmacology Nursing Public Health Other

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Journal : Journal of Agromedicine and Medical Sciences

 1 
Potential of Cocoa Extract (Theobroma cacao) in Inhibiting Erythrocyte Damage Induced by Physalia utriculus Venom Adinningtyas Intansari; Al Munawir; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.9661

Abstract

Physalia utriculus is one of the invertebrate marine biota that is often found in Indonesia. Some symptoms of venoming due to jellyfish stings cause pain, itching, and hemolysis. In Indonesia, 13 cases of jellyfish stings were reported in 2005-2009 with three people dying in Java, Bali, and Bangka. Cocoa beans (Theobroma cacao L.) contain fat, carbohydrates, proteins, and polyphenol compounds that are useful as antioxidants. Polyphenols in the form of epicathechins, catechins, and procyanidins serve to provide protection to hemolysis. The purpose of this study was to determine the potential of ethanol extract of cacao (Theobroma cacao L.) in inhibiting the damage of erythrocyte induced by Physalia utriculus in vitro. This study used 28 samples of erythrocytes divided into seven groups, namely the normal control group, negative controls, and treatment with cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02%. Each subsequent group induced venom Physalia utriculus. The results showed that the average speed of erythrocyte lysis in the treatment group by giving cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02% respectively (seconds ± standard deviation) was 858,25 ± 94,44; 1.000,5 ± 159,93; 678,5 ± 19,71; and 1.006 ± 159,50. The mean speed of erythrocyte lysis in the negative control group was 1,025 ± 164.63 and the positive control group with the administration of N-Acetylcystein can last up to one hour after administration of venoms. Test for normality and homogeneity shows that data is normally distributed and homogeneous. One Way Annova analysis shows the significance value of p <0.05, then a post hoc analysis test was performed with the Bonferoni method to find out the differences in significance in each group. In this study it can be concluded that the administration of cocoa ethanol extract has no potential to inhibit erythrocyte damage that has been venomed by Physalia utriculus in vitro. Keywords: Physalia utriculus, cacao, erythrocyte damage
The Effect Of Folic On Different Dosage Level Against Retina Destruction Level Of Mice With Peroral Methanol 50% I Gusti Ngurah Agung Darma Putra; Al Munawir; Sugiyanta sugiyanta
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5066

Abstract

In recent years, there are many methanol poisoned cases. Methanol poisoned cause of blindness, CNS problem, and metabolic acidosis. Folic acid is the one of many medicinal treatment for methanol poisoned. Folic acid has important role on methanol metabolism in our body. The aim of the study was to known the effect of addition folic acid on retina damage level of methanol poisoned. The method is experimental laboratories (true experiment design) with post test only control group design. The study included 5 separate test. The subject were mice which in 2 - 3 months age and had weight about 25 - 35 gr. There were 5 groups subject in the study. There were control group which given usual meals for mice and aquadest, negative control group which given methanol 7gr/ kgBW, treatment group 1,2, and 3 were given methanol 7gr/kgBW and folic acid 1 mg/kg BW, 3mg/kgBW, and 5 mg/kgBW. The treatment was given about 24 hours, then the eyes of the mice were taken to made blood smear. Damage of eyes were evaluated based score determined before. It can be concluded that addition folic acid can reduce retina damage level of metanol poisoned.
Potential of Cocoa Ethanol Extract Toward Nematocyst Tubul Firing Inhibition of Physalia Utriculus Toxin In Vitro Sarwendah Siswi Winasis; Al Munawir; Adelia Handoko
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9623

Abstract

There was estimated 150 million envenomation cases due to jellyfish stings occur globally every year. 100 from 10,000 jellyfish species in the world known to be dangerous, one them is Physalia utriculus. The aim of this study was to determine the potential of cocoa (Theobroma cacao L.) ethanol extract toward nematocyst tubul firing inhibition of jellyfish (Physalia utriculus) toxin in vitro. The method was true experimental design with post test only control group design. The study divided into 8 groups: 1 normal control, 1 positive control, 1 negative control, and 5 treatments grups by giving cocoa ethanol extract with concentration 20%, 2%, 0.2%, 0.02%, 0.002%. The observation was made by calculating the percentage number of firing nematocysts. The result showed average percentage of firing nematocyst in the normal control group was 42.50 ± 3.18, positive control group was 37.97 ± 5.57, negative control group was 52.44 ± 2.98, and treatment group which given with cocoa ethanol extract 20%, 2%, 0.2%, 0.02%, 0.002% were 48.24 ± 5.37; 40.62 ± 7.10; 29.45 ± 5.39; 37.60 ± 9.78; 41.11 ± 3.92, respectively. The One Way Annova statistical results test show significance value 0.001 (p≤0.05). The conclusion of this study was the cocoa ethanol extract with concentration 0.2% has most potential to inhibit the jellyfish (P. utriculus) nematocyst tubule firing in vitro. Keywords: Physalia utriculus, cocoa, toxin, jellyfish
Co-Authors Ade Ananta Pratiwi Adelia Handoko Adinningtyas Intansari Agung Sudrajat Agung_Sudrajat Agung Aini Hidayati Ali Santoso Alimas Jonsa Anang Dwi Atmoko Ancah Caesarina Novi Marchianti Anhar Fazri Asti Nuris ASTUTI, IDA SRI SURANI WIJI Ayik Nikmatul Laili Ayik Nikmatul laili Azka Darajat Bagus Indra Kusuma Dear F Sielma Desy Tariustanti Desy Tariustanti Dewi Rokhmah Edy Kurniawan Elfian Zulkarnain Elfian Zulkarnain, Elfian Erfan Efendi Erma Sulistyaningsih Fadhly, Zuhrizal Farida Wahyu Ningtyias, Farida Wahyu Farida Wahyuningtiyas Farizal, Teuku Fazlina, Rita Ghiza J.K. Barqly Hadi Prayitno Hazmi Dwinanda Nurqistan Herdi Susanto Herri Darsan Hilda Khairinnisa I Gusti Ngurah Agung Darma Putra Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Ikmala, Riskita Isa Marufi ISLAMI, SHOFI IQDA Jumanto Jumanto Kiky Martha Ariesaka kustin uds Laili, Ayik Nikmatul Laksmi Indreswari Luluk Faridatul Mukaromah Mudzakkir Taufiqurrahman Murhaban Murhaban Murtadho Ridwan Nadia Putri Yurianto Nafolion Nur Rahmat Nafolion Nur Rahmat, Nafolion Nur Nanda Prima Natasya Febrilia Yulianti Novan K. Adji Pandan wangi Pandan Putri Erlinda Kusumaningarum Putri Kemala Sari Retno Widyastuti Riskita Ikmala Rizka N Wardani Roat Yeti Mustafida Rosita Dewi Sabrina M Pratama Saiful Bukhori Saiful Bukhori Saiful Bukhori Salman Al Farisi Sarwendah Siswi Winasis Sayyidah Auliany Aminy septa surya wahyudi, septa surya SHOFI IQDA ISLAMI Silvi Ahmada Chasya Sri Wahyu Handayani, Sri Wahyu Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat Supangat Syari, Zammiq Ummah, Wiqodatul Vita Alfiatul Hasanah Wahyu Dian Puspita Wiqodatul Ummah Zahrah Febianti Zarah Puspita Zarah Puspitaningtyas